The automatic process control system for liquid preparation is based on the requirements of the liquid preparation process, combined with the most advanced technologyAutomation controlA set of automated production process control system developed through technology. This system can ensure the automatic operation of various production sub processes of large infusion, and can monitor and alarm the production process parameters in real time, accurately control the solution temperature, injection water temperature, and sterilization effect to ensure production quality. At the same time, it can also query the historical data and operation records of all parameters, greatly improving the automation efficiency of the production process!

Application industry: It can be applied to industries such as biomedicine, veterinary medicine, powder injections, small injections, and traditional Chinese medicine dispensing systems.

Note: The system is customized according to user requirements (URS).

In order to meet the requirements of the new version《The GMP standard and the automation of production in the pharmaceutical industry have been increasingly widely applied, especially in the urgent need for automated control of liquid dispensing in pharmaceutical factories; Based on the trend of production automation in the pharmaceutical industry, our company has independently developed an automated liquid dispensing control system, which not only achieves liquid dispensing automation, but also achieves online CIP cleaning and online SIP disinfection of the entire system, as well as online integrity testing of microporous membrane filters. Taking 300L concentrated mixing as an example, the corresponding diluted mixing tank capacity is 800L. The configuration of the concentrated mixing tank is: bottom stirring - magnetic stirring, and the reducer is a German made "SEW" reducer with a motor power of 0.75KW; the pneumatic diaphragm valve at the bottom of the tank is DN32; Electric heating respirator, 5 "× 1 core PTFE filter, 0.22 μ m; Digital thermometer interface - sterile flange type; Digital level gauge interface - sterile flange type; Sampling valve interface - sterile flange type; Quick installation manhole, integrated light mirror, diaphragm pressure gauge, with bursting disc safety valve; Steam inlet supporting role seat valve, condensate outlet pneumatic ball valve; And several quick installation interfaces - inlet with flow meter. Configuration of dilution tank: The dilution tank is a key tank for preparing liquid medicine, which directly affects the quality of liquid preparation. Therefore, the configuration requirements are relatively high. The dilution tank needs to be equipped with a weighing system, imported from abroad, and a Mettler Toledo weighing module with a specification of CWC-1.5 stainless steel dynamic load module, including a weighing display screen; Bottom stirring - magnetic stirring, and the reducer is a "SEW" reducer from a German factory, with a motor power of 1.5KW; the pneumatic diaphragm valve at the bottom of the tank is DN32; Electric heating respirator, 5 ″ × 1 PTFE filter element, 0.22 μ m; Digital thermometer interface - sterile flange type; PH meter interface - sterile flange type; Sampling valve interface - sterile flange type; Quick installation manhole, integrated light mirror, diaphragm pressure gauge, with bursting disc safety valve; Steam inlet supporting role seat valve, condensate outlet pneumatic ball valve; And several quick install interfaces.

The dispensing, CIP cleaning, and SIP disinfection of the entire dispensing system are automatically controlled by a PLC program, and some parameters are printed out through a set printer; By analyzing the parameters, determine whether the liquid preparation system is correct, whether CIP cleaning and SIP disinfection are qualified, and thus determine whether the entire liquid preparation system is sterile and safe.

A conductivity meter is installed at the bottom of the mixing tank to determine the degree of cleaning between the tank and the pipeline based on the conductivity value; It is worth noting that the conductivity of distilled water is 0.05-0.1 μ s/cm, and the conductivity of purified water is 1.0-10 μ s/cm; During cleaning, if purified water is used for washing, the degree of cleaning should be based on the conductivity range of the purified water; If distilled water is used for washing, the degree of cleaning should be based on the conductivity range of distilled water; During the pipeline cleaning process, it is also necessary to control the conductivity meter. During the cleaning process, observe the displayed conductivity value on the pipeline, compare it with the conductivity range of distilled water and purified water, and analyze the degree of pipeline cleaning.

During the SIP disinfection process of the liquid preparation system, the sterilization and disinfection temperature needs to be considered. Therefore, a stainless steel dial thermometer is installed at the bottom of each tank to determine the temperature during tank and pipeline disinfection based on the displayed value of the thermometer; The saturated steam temperature used for sterilization and disinfection is 121 ℃, and it is continuously disinfected at this temperature for 30 minutes. During this process, pure steam is converted into condensed water, which is discharged through the pneumatic diaphragm valve at the bottom of the tank, the pneumatic diaphragm valve on the pipeline, and the pneumatic sanitary ball valve.