Agilent liquid chromatography columnIntroduction:Affinity, ion exchange, and volume exclusion chromatography are commonly used techniques for analyzing proteins such as monoclonal antibodies. However, these technologies require an aqueous mobile phase containing non-volatile salts. When using mass spectrometry for detection, these non-volatile salts can cause signal suppression and salt deposition can contaminate the mass spectrometer detector, resulting in increased maintenance requirements and prolonged instrument downtime.Agilent liquid chromatography columnAdvanceBio desalination reverse phase columnBy solving this problem, salt ions can be quickly and efficiently removed online before mass spectrometry detection. This type of small column chromatography column can be used alone in any liquid chromatography system to remove salts from collected fractions, or it can also be used as the second dimension of the Agilent 1290 Infinity II two-dimensional liquid chromatography system for desalination after separation in the * dimension.

characteristic

• Enable traditional non mass spectrometry friendly technologies such as IEX, SEC, and affinity chromatography to be detected using mass spectrometry
• Online desalination of samples effectively saves time
• Enrich the sample before elution
• Keeping the mass spectrometry cleaner reduces downtime and minimizes maintenance
• Improve data quality to give you full confidence in overall data
• Featuring a large particle size of 1000 Å, suitable for large biomolecules
• Stable within the pH range of 2-13
• Compatible with all commonly used reverse flow phases

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